Open AccessLarge-Scale Outbreak of Infection with Mycobacterium chelonae subsp. abscessus after Penicillin Injection
Author(s) -
Zhibang Yang,
Bixia Zhang,
Lu Qishan,
Li-Hao Chen,
Xiangquan Liu,
Huaping Li
Publication year - 2002
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.40.7.2626-2628.2002
Subject(s) - penicillin , microbiology and biotechnology , mycobacterium chelonae , vial , outbreak , sterilization (economics) , antibiotics , mycobacterium abscessus , mycobacterium , biology , bacteria , gel electrophoresis , chemistry , virology , chromatography , genetics , monetary economics , foreign exchange , economics , foreign exchange market
An outbreak of infection with Mycobacterium chelonae subsp. abscessus after the injection of penicillin in 86 patients attending a factory hospital is reported. The bacterium was isolated both from lids and from the soil where the drug was stored. Molecular analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis of whole-cell proteins and plasmids revealed a pattern identical to that of the strains isolated from the wounds. The source of the infections was soil contamination of the vial lids and was caused by improper use and sterilization of penicillin vials.