Open AccessDiversity of Rotavirus Strains among Children with Acute Diarrhea in China: 1998-2000 Surveillance Study
Author(s) -
Zhao-Yin Fang,
Hui Yang,
Jin Qi,
Jing Zhang,
Liwei Sun,
Jingyu Tang,
Li Ma,
Zhenguo Du,
He AiHua,
Jian-ping Xie,
YiYu Lu,
Zhenzhou Ji,
Bo Zhu,
Hongyan Wu,
Sien Lin,
Hua Xie,
Dixie D. Griffin,
B Ivanoff,
Roger I. Glass,
Jon R. Gentsch
Publication year - 2002
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.40.5.1875-1878.2002
Subject(s) - rotavirus , diarrhea , serotype , genotype , feces , acute diarrhea , acute gastroenteritis , virology , biology , molecular epidemiology , reoviridae , microbiology and biotechnology , medicine , gastroenterology , gene , genetics
As part of a national rotavirus surveillance activity, we collected fecal specimens from 3,177 children with acute diarrhea in 10 regions of China between April 1998 and April 2000 and screened them for rotavirus. Rotavirus was detected in 41% (n = 1,305) of specimens, and in these, G1 was the predominant serotype (72.6%), followed by G3 (14.2%), G2 (12.1%), G4 (2.5%), G9 (0.9%), and G untypeable (0.7%). Among 327 G-typed strains tested for P genotype, 14 different P-G combinations were identified, with the globally common strains P[8]G1, P[4]G2, P[8]G3, and P[8]G4 representing 75.6% of all typed rotavirus strains. Among the uncommon strains, 11 were P[6]G9, and others included P[6]G1, P[6]G3, and five novel P-G combinations (P[9]G1, P[4]G1, P[4]G3, P[4]G4, and P[8]G2). Our results indicate that while the common rotavirus strains remain predominant, the diversity of strains is much greater than was previously recognized.