Open AccessComparison of Sequence Analysis and the INNO-LiPA HBV DR Line Probe Assay for Detection of Lamivudine-Resistant Hepatitis B Virus Strains in Patients under Various Clinical Conditions
Author(s) -
Stephan W. Aberle,
Josef Kletzmayr,
Bruno Watschinger,
Brigitte Schmied,
N Vetter,
Elisabeth PuchhammerStöckl
Publication year - 2001
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.39.5.1972-1974.2001
Subject(s) - virology , lamivudine , hepatitis b virus , hepatitis b , virus , orthohepadnavirus , biology , hepadnaviridae , medicine
A line probe assay (INNO-LiPA HBV DR) detecting drug-resistant hepatitis B virus (HBV) strains was evaluated. Results concordant with sequence analysis were obtained with 48 of 56 serum samples from HBV-infected patients undergoing lamivudine therapy. In eight cases, additional minor subpopulations could be identified by the line probe assay.