Open AccessInvasive Fungal Sinusitis and Meningitis Due to Arthrographis kalrae in a Patient with AIDS
Author(s) -
Peter ChinHong,
Deanna A. Sutton,
Marguerite Roemer,
Mark A. Jacobson,
Judith A. Aberg
Publication year - 2001
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.39.2.804-807.2001
Subject(s) - meningitis , sinusitis , medicine , pneumonia , vasculitis , mycosis , itraconazole , brain abscess , pathology , surgery , dermatology , abscess , antifungal , disease
We report the first described case of Arthrographis kalrae pansinusitis and meningitis in a patient with AIDS. The patient was initially diagnosed with Arthrographis kalrae pansinusitis by endoscopic biopsy and culture. The patient was treated with itraconazole for approximately 5 months and then died secondary to Pneumocytis carinii pneumonia. Postmortem examination revealed invasive fungal sinusitis that involved the sphenoid sinus and that extended through the cribiform plate into the inferior surfaces of the bilateral frontal lobes. There was also an associated fungal meningitis and vasculitis with fungal thrombosis and multiple recent infarcts that involved the frontal lobes, right caudate nucleus, and putamen. Post mortem cultures were positive for A. kalrae.