Extremely high titers of serum antibodies against the streptococcal exoenzyme deoxyribonuclease B | Zendy

B Hederstedt | Zendy; S. E. Holm | Zendy; R Norberg | Zendy

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Extremely high titers of serum antibodies against the streptococcal exoenzyme deoxyribonuclease B

Author(s) -

B Hederstedt,

S. E. Holm,

R Norberg

Publication year - 1980

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.11.6.720-723.1980

Subject(s) - deoxyribonuclease , titer , antibody , medicine , immunology , immunoglobulin m , microbiology and biotechnology , streptococcaceae , immunoglobulin g , biology , enzyme , antibiotics , biochemistry

In sera from 4 of 25,000 individuals tested for antibodies against streptococci, extremely high antideoxyribonuclease B titers ( > 10(6) U/ml) were found. Two of the cases were diagnosed as monoclonal gammopathies. The M-components were shown to possess the anti-deoxyribonuclease B activity. The other two cases were diagnosed as relapsing erysipelas. The high serum titers of deoxyribonuclease B antibodies were accompanied by a very inflammatory reactivity in the patients' sera and by an oligopolyclonal pattern of immunoglobulin G. In routine diagnoses of streptococcal infections with the anti-deoxyribonuclease B test, patients with extremely high serum titers should be examined for the possible occurrence of gammopathies.

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