Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients | Zendy

Vincent Descamps | Zendy; Anne Op De Beeck | Zendy; C. Plassart | Zendy; Étienne Brochot | Zendy; Catherine François | Zendy; François Helle | Zendy; Michael Adler | Zendy; Nadine Bourgeois | Zendy; Delphine Degré | Zendy; Gilles Duverlie | Zendy; Sandrine Castelain | Zendy

Open Access

Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

Author(s) -

Vincent Descamps,

Anne Op De Beeck,

C. Plassart,

Étienne Brochot,

Catherine François,

François Helle,

Michael Adler,

Nadine Bourgeois,

Delphine Degré,

Gilles Duverlie,

Sandrine Castelain

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.06503-11

Subject(s) - virology , antigen , rna , virus , biology , immunology , viral disease , medicine , genetics , gene

HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.

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