Open AccessDetection of Carbapenemase Producers in Enterobacteriaceae by Use of a Novel Screening Medium
Author(s) -
Patrice Nordmann,
Delphine Girlich,
Laurent Poirel
Publication year - 2012
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.06477-11
Subject(s) - cloxacillin , enterobacteriaceae , microbiology and biotechnology , ertapenem , agar , biology , escherichia coli , bacteria , antibiotics , imipenem , antibiotic resistance , genetics , biochemistry , gene , penicillin
A Drigalski agar-based culture medium containing an ertapenem, cloxacillin, and zinc sulfate (Supercarba medium) was tested for screening carbapenemase-producing members of the family Enterobacteriaceae. OXA-48 (n = 44), NDM (n = 25), VIM or IMP (n = 27), and KPC producers (n = 18) were detected with a low detection limit. Its overall sensitivity (95.6%) was higher than those of the currently available ChromID ESBL (bioMérieux) and CHROMagar KPC (CHROMagar) screening media. The Supercarba medium provides a significant improvement for detection of the most common types of carbapenemase producers.
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