Open AccessIndividual Plasmodium vivax msp1 Variants within Polyclonal P. vivax Infections Display Different Propensities for Relapse
Author(s) -
Jessica T. Lin,
Jonathan J. Juliano,
Oksana Kharabora,
Rithy Sem,
FengChang Lin,
Sinuon Muth,
Didier Ménard,
Chansuda Wongsrichanalai,
William O. Rogers,
Steven R. Meshnick
Publication year - 2012
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.06212-11
Subject(s) - plasmodium vivax , biology , parasitemia , heteroduplex , polyclonal antibodies , virology , genotype , gene , malaria , genetics , immunology , antibody , plasmodium falciparum
Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently in the initial genotypes of those who developed recurrent parasitemia, representing the first time P. vivax variants associated with a higher risk of relapse have been described.