Open AccessPerformance of the MGIT TBc Identification Test and Meta-Analysis of MPT64 Assays for Identification of the Mycobacterium tuberculosis Complex in Liquid Culture
Author(s) -
Andrew Brent,
Daisy Mugo,
Robert Musyimi,
Agnes Mutiso,
Susan C. Morpeth,
Michael Levin,
J. Anthony G. Scott
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.05995-11
Subject(s) - mycobacterium tuberculosis , identification (biology) , microbiology and biotechnology , tuberculosis , liquid culture , mycobacterium tuberculosis complex , mycobacterium , computational biology , biology , medicine , pathology , botany
Rapid MPT64-based immunochromatographic tests (MPT64 ICTs) have been developed to detect Mycobacterium tuberculosis complex (MTBC) in culture. We demonstrated the noninferiority of one commercial MTP64 ICT, the MGIT TBc identification (TBcID) test, to GenoType line probe assays for MTBC identification in positive MGIT cultures. Meta-analysis of MPT64 ICT performance for identification of MTBC in liquid culture confirmed similar very high sensitivities and specificities for all three commercial MPT64 assays for which sufficient data were available.
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