Open AccessGlutamate Dehydrogenase Is Highly Conserved among Clostridium difficile Ribotypes
Author(s) -
Robert J. Carman,
K. N. Wickham,
L. Chen,
A. M. Lawrence,
James H. Boone,
T D Wilkins,
Thomas M. Kerkering,
David M. Lyerly
Publication year - 2012
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.05600-11
Subject(s) - glutamate dehydrogenase , clostridium difficile , clostridiaceae , biology , microbiology and biotechnology , clostridium , enzyme , in vitro , clostridiales , biochemistry , bacteria , glutamate receptor , genetics , antibiotics , receptor
gluD was highly conserved and glutamate dehydrogenase (GDH) was readily expressed in vitro by all 77 Clostridium difficile ribotypes assayed. All ribotypes, including ARL 002, ARL 027, and ARL 106, were reactive in assays that detect C. difficile GDH.
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