Open AccessUse of Quantitative HIV RNA Detection for Early Diagnosis of HIV Infection in Infants and Acute HIV Infections in Alberta, Canada
Author(s) -
Bonita E. Lee,
Sabrina S. Plitt,
Gayatri Jayaraman,
Linda Chui,
Ameeta E. Singh,
Jutta K. Preiksaitis
Publication year - 2011
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.05471-11
Subject(s) - human immunodeficiency virus (hiv) , virology , viral load , viral disease , medicine , sida , immunology , lentivirus , biology
Quantitative HIV RNA viral load (QVL) assays (Roche Diagnostics) were sensitive and specific when used to diagnose HIV infection in (i) HIV-exposed infants (sensitivity of 100% [63.1 to 100%] and specificity of 100% [97.9 to 100%]) and (ii) suspected acute HIV infection patients with a negative/indeterminate Western blot (sensitivity of 97.6% [91.6 to 99.7%] and specificity of 100% [96.1 to 100%]). No false-positive QVL results were identified.
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