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Mycobacterium avium is abundant in the environment. It has four subspecies of three types: the human or porcine type,M. avium subsp.hominissuis ; the bird type, includingM. avium subsp.avium serotype 1 and serotype 2, 3 (alsoM. avium subsp.silvaticum ); and the ruminant type,M. avium subsp.paratuberculosis . We determined the subspecies of 257M. avium strains isolated from patients at the M.D. Anderson Cancer Center from 2001 to 2010 and assessed their clinical significance. An assay of multiplex PCR was used for the typing. Results showedM. avium subsp.hominissuis to be most common (n = 238, 92.6%), followed byM. avium subsp.avium serotype 1 (n = 12, 4.7%) and serotype 2, 3 (n = 7, 2.7%). No strains ofM. avium subsp.paratuberculosis were found. Of the 238 patients withM. avium subsp.hominissuis , 65 (27.3%) showed evidence of definite or probable infections, mostly in the respiratory tract, whereas the rest had weak evidence of infection. The bird-type subspecies, despite being infrequently isolated, caused relatively more definite and probable infections (10 of 19 strains, 52.6%). Overall, women of 50 years of age or older were more prone toM. avium infection than younger women or men of all ages were. We therefore conclude thatM. avium subsp.hominissuis is the dominantM. avium subspecies clinically, that the two bird-type subspecies do cause human infections, and thatM. avium infects mainly postmenopausal women. The lack of human clinical isolation of the ruminant type subspecies may need further investigation.

Subspecies Identification and Significance of 257 Clinical Strains of Mycobacterium avium