Serum Arginase, a Biomarker of Treatment Efficacy in Human African Trypanosomiasis | Zendy

Romaric NzoumbouBoko | Zendy; Mariette Dethoua | Zendy; Frédéric Gabriel | Zendy; Alain Buguet | Zendy; Raymond Cespuglio | Zendy; Pierrette Courtois | Zendy; Sylvie Daulouède | Zendy; Bernard Bouteille | Zendy; Stéphane Ngampo | Zendy; Ghislain Armel Mpandzou | Zendy; Silla Semballa | Zendy; Philippe Vincendeau | Zendy

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Serum Arginase, a Biomarker of Treatment Efficacy in Human African Trypanosomiasis

Author(s) -

Romaric NzoumbouBoko,

Mariette Dethoua,

Frédéric Gabriel,

Alain Buguet,

Raymond Cespuglio,

Pierrette Courtois,

Sylvie Daulouède,

Bernard Bouteille,

Stéphane Ngampo,

Ghislain Armel Mpandzou,

Silla Semballa,

Philippe Vincendeau

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.03371-12

Subject(s) - arginase , african trypanosomiasis , ornithine , biomarker , arginine , immune system , trypanosomiasis , immunology , biology , biochemistry , amino acid

Arginase serum levels were increased in human African trypanosomiasis patients and returned to control values after treatment. Arginase hydrolyzes l-arginine to l-ornithine, which is essential for parasite growth. Moreover, l-arginine depletion impairs immune functions. Arginase may be considered as a biomarker for treatment efficacy.

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