Diagnosis of Prosthetic Joint Infection by Use of PCR-Electrospray Ionization Mass Spectrometry | Zendy

Kerryl E. GreenwoodQuaintance | Zendy; James R. Uhl | Zendy; Arlen D. Hanssen | Zendy; Rangarajan Sampath | Zendy; Jayawant N. Mandrekar | Zendy; Robin Patel | Zendy

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Diagnosis of Prosthetic Joint Infection by Use of PCR-Electrospray Ionization Mass Spectrometry

Author(s) -

Kerryl E. GreenwoodQuaintance,

James R. Uhl,

Arlen D. Hanssen,

Rangarajan Sampath,

Jayawant N. Mandrekar,

Robin Patel

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.03217-13

Subject(s) - electrospray ionization , aseptic processing , mass spectrometry , electrospray , medicine , polymerase chain reaction , chromatography , microbiology and biotechnology , chemistry , biology , surgery , gene , biochemistry

We compared PCR-electrospray ionization mass spectrometry (PCR-ESI/MS) to culture using sonicate fluid from 431 subjects with explanted knee (n = 270) or hip (n = 161) prostheses. Of these, 152 and 279 subjects had prosthetic joint infection (PJI) and aseptic failure, respectively. The sensitivities for detecting PJI were 77.6% for PCR-ESI/MS and 69.7% for culture (P = 0.0105). The specificities were 93.5 and 99.3%, respectively (P = 0.0002).

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