Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data | Zendy

Anna E. Sheppard | Zendy; Alison Vaughan | Zendy; Nicola Jones | Zendy; Paul Turner | Zendy; Claudia Turner | Zendy; Androulla Efstratiou | Zendy; Darshana Patel | Zendy; Timothy M. Walker | Zendy; James A. Berkley | Zendy; Derrick W. Crook | Zendy; Anna C. Seale | Zendy

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Capsular Typing Method for Streptococcus agalactiae Using Whole-Genome Sequence Data

Author(s) -

Anna E. Sheppard,

Alison Vaughan,

Nicola Jones,

Paul Turner,

Claudia Turner,

Androulla Efstratiou,

Darshana Patel,

Timothy M. Walker,

James A. Berkley,

Derrick W. Crook,

Anna C. Seale

Publication year - 2016

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.03142-15

Subject(s) - streptococcus agalactiae , biology , typing , whole genome sequencing , multilocus sequence typing , microbiology and biotechnology , streptococcus , genome , sequence (biology) , genetics , computational biology , gene , bacteria , genotype

Group B streptococcus (GBS) capsular serotypes are major determinants of virulence and affect potential vaccine coverage. Here we report a whole-genome-sequencing-based method for GBS serotype assignment. This method shows strong agreement (kappa of 0.92) with conventional methods and increased serotype assignment (100%) to all 10 capsular types.

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