Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam–β-Lactamase Inhibitor Combinations | Zendy

Gina K. Thomson | Zendy; James W. Snyder | Zendy; Christi L. McElheny | Zendy; Kenneth S. Thomson | Zendy; Yohei Doi | Zendy

Open Access

Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter cloacae: Implications for Newer β-Lactam–β-Lactamase Inhibitor Combinations

Author(s) -

Gina K. Thomson,

James W. Snyder,

Christi L. McElheny,

Kenneth S. Thomson,

Yohei Doi

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02739-15

Subject(s) - enterobacter cloacae , enterobacter , microbiology and biotechnology , enterobacteriaceae infections , lactam , beta lactam , enterobacteriaceae , biology , antibiotics , chemistry , genetics , escherichia coli , gene , stereochemistry

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes,bla KPC-18 andbla VIM-1 . Whole-genome sequencing localizedbla KPC-18 to the chromosome andbla VIM-1 to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam–β-lactamase inhibitor combinations.

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