Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing | Zendy

Peter M. Kinnevey | Zendy; Anna C. Shore | Zendy; Micheál Mac Aogáin | Zendy; Eilish Creamer | Zendy; Gráinne I. Brennan | Zendy; H. Humphreys | Zendy; Thomas R. Rogers | Zendy; Brian O’Connell | Zendy; David C. Coleman | Zendy

Open Access

Enhanced Tracking of Nosocomial Transmission of Endemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Type IV Isolates among Patients and Environmental Sites by Use of Whole-Genome Sequencing

Author(s) -

Peter M. Kinnevey,

Anna C. Shore,

Micheál Mac Aogáin,

Eilish Creamer,

Gráinne I. Brennan,

H. Humphreys,

Thomas R. Rogers,

Brian O’Connell,

David C. Coleman

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02662-15

Subject(s) - methicillin resistant staphylococcus aureus , whole genome sequencing , staphylococcus aureus , biology , typing , staphylococcal infections , molecular epidemiology , transmission (telecommunications) , microbiology and biotechnology , virology , genome , genetics , gene , genotype , bacteria , electrical engineering , engineering

Whole-genome sequencing (WGS) of 41 patient and environmental sequence type 22 methicillin-resistantStaphylococcus aureus staphylococcal cassette chromosomemec type IV (ST22-MRSA-IV) isolates recovered over 6 weeks in one acute hospital ward in Dublin, Ireland, where ST22-MRSA IV is endemic, revealed 228 pairwise combinations differing by <40 single nucleotide variants corresponding to potential cross-transmission events (CTEs). In contrast, 15 pairwise combinations of isolates representing five CTEs were previously identified by conventional molecular epidemiological typing. WGS enhanced ST22-MRSA-IV tracking and highlighted potential transmission of MRSA via the hospital environment.

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