Strain-Tailored Double-Disk Synergy Test Detects Extended-Spectrum Oxacillinases in Pseudomonas aeruginosa | Zendy

Didier Hocquet | Zendy; Barbara Dehecq | Zendy; Xavier Bertrand | Zendy; Patrick Plésiat | Zendy

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Strain-Tailored Double-Disk Synergy Test Detects Extended-Spectrum Oxacillinases in Pseudomonas aeruginosa

Author(s) -

Didier Hocquet,

Barbara Dehecq,

Xavier Bertrand,

Patrick Plésiat

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02585-10

Subject(s) - ceftazidime , cefepime , pseudomonas aeruginosa , imipenem , microbiology and biotechnology , strain (injury) , pseudomonadaceae , pseudomonadales , biology , bacteria , genetics , anatomy

The prevalence of class D extended-spectrum oxacillinases (ES-OXAs) in ceftazidime-resistant strains of Pseudomonas aeruginosa is often underestimated by double-disk synergy tests (DDST) using clavulanate. A DDST with a customized distance between a disk of ceftazidime or cefepime and inhibitors (clavulanate and imipenem) detected 14 out of 15 different ES-OXAs.

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