Rapid Detection of Campylobacter Antigen by Enzyme Immunoassay Leads to Increased Positivity Rates | Zendy

Carmen L. Giltner | Zendy; Sandra Saeki | Zendy; April M. Bobenchik | Zendy; Romney M. Humphries | Zendy

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Rapid Detection of Campylobacter Antigen by Enzyme Immunoassay Leads to Increased Positivity Rates

Author(s) -

Carmen L. Giltner,

Sandra Saeki,

April M. Bobenchik,

Romney M. Humphries

Publication year - 2012

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02565-12

Subject(s) - immunoassay , campylobacter , predictive value , antigen , enzyme , microbiology and biotechnology , biology , virology , medicine , immunology , antibody , bacteria , biochemistry , genetics

Campylobacter antigen detection by enzyme immunoassay (EIA) provides rapid results compared to traditional culture. However, concern exists regarding specificity. Verification studies of an EIA compared to culture revealed a positive predictive value (PPV) of 91%, whereas PPV fell to 42% during routine diagnostic testing. We suggest all positive EIA results be confirmed via culture.

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