Optimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays | Zendy

Violette Dirix | Zendy; Nicolás Dauby | Zendy; Maya Hites | Zendy; Emmanuelle Watelet | Zendy; Anne Van Praet | Zendy; Audrey Godefroid | Zendy; Emmanuelle Petit | Zendy; Mahavir Singh | Zendy; Camille Locht | Zendy; Françoise Mascart | Zendy; Véronique Corbière | Zendy

Open Access

Optimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays

Author(s) -

Violette Dirix,

Nicolás Dauby,

Maya Hites,

Emmanuelle Watelet,

Anne Van Praet,

Audrey Godefroid,

Emmanuelle Petit,

Mahavir Singh,

Camille Locht,

Françoise Mascart,

Véronique Corbière

Publication year - 2022

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02443-21

Subject(s) - mycobacterium tuberculosis , virology , hemagglutinin (influenza) , interferon gamma , antigen , interferon gamma release assay , tuberculosis , microbiology and biotechnology , biology , esat 6 , immunology , latent tuberculosis , medicine , cytokine , pathology

Optimal detection of latent tuberculosis (TB) infection (LTBI) remains a challenge, although it is essential to reach the goal of TB elimination. Our objective was to develop and clinically evaluate a user-friendly, 24-h, whole-blood (WB) interferon gamma (IFN-γ) release assay (IGRA) improving the detection of LTBI, compared to available tests.

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