Open AccessOptimal Detection of Latent Mycobacterium tuberculosis Infection by Combined Heparin-Binding Hemagglutinin (HBHA) and Early Secreted Antigenic Target 6 (ESAT-6) Whole-Blood Interferon Gamma Release Assays
Author(s) -
Violette Dirix,
Nicolás Dauby,
Maya Hites,
Emmanuelle Watelet,
Anne Van Praet,
Audrey Godefroid,
Emmanuelle Petit,
Mahavir Singh,
Camille Locht,
Françoise Mascart,
Véronique Corbière
Publication year - 2022
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.02443-21
Subject(s) - esat 6 , mycobacterium tuberculosis , latent tuberculosis , interferon gamma release assay , interferon gamma , tuberculosis , hemagglutinin (influenza) , virology , whole blood , immunology , antigen , mycobacterium tuberculosis complex , medicine , microbiology and biotechnology , biology , cytokine , pathology
Optimal detection of latent tuberculosis (TB) infection (LTBI) remains a challenge, although it is essential to reach the goal of TB elimination. Our objective was to develop and clinically evaluate a user-friendly, 24-h, whole-blood (WB) interferon gamma (IFN-γ) release assay (IGRA) improving the detection of LTBI, compared to available tests.