No Correlation between Giant Cell Arteritis and Chlamydia pneumoniae Infection: Investigation of 189 Patients by Standard and Improved PCR Methods | Zendy

Florence Njau | Zendy; Thomas Neß | Zendy; Ulrike Wittkop | Zendy; Thorsten Pancratz | Zendy; Meike Eickhoff | Zendy; Alan P. Hudson | Zendy; Hermann Haller | Zendy; Annette D. Wagner | Zendy

Open Access

No Correlation between Giant Cell Arteritis and Chlamydia pneumoniae Infection: Investigation of 189 Patients by Standard and Improved PCR Methods

Author(s) -

Florence Njau,

Thomas Neß,

Ulrike Wittkop,

Thorsten Pancratz,

Meike Eickhoff,

Alan P. Hudson,

Hermann Haller,

Annette D. Wagner

Publication year - 2009

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02438-08

Subject(s) - giant cell arteritis , chlamydia , chlamydophila pneumoniae , chlamydiaceae , chlamydiales , pathogenesis , biology , arteritis , polymerase chain reaction , immunology , pathology , virology , medicine , vasculitis , gene , genetics , disease

A total of 189 temporal artery biopsy samples from giant cell arteritis (GCA) patients were investigated using sensitive PCR targeting Chlamydia pneumoniae. Chlamydial DNA was detected in 17 samples, 11 of which were positive for chlamydial antigens. Our data did not reveal strong evidence that C. pneumoniae plays an important role in the pathogenesis of GCA.

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