Comparison of the Broth Microdilution Methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical and Laboratory Standards Institute for Testing Itraconazole, Posaconazole, and Voriconazole against Aspergillus Isolates | Zendy

Michael A. Pfaller | Zendy; L. Boyken | Zendy; R. J. Hollis | Zendy; J. Kroeger | Zendy; S. A. Messer | Zendy; S. Tendolkar | Zendy; Daniel J. Diekema | Zendy

Open Access

Comparison of the Broth Microdilution Methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical and Laboratory Standards Institute for Testing Itraconazole, Posaconazole, and Voriconazole against Aspergillus Isolates

Author(s) -

Michael A. Pfaller,

L. Boyken,

R. J. Hollis,

J. Kroeger,

S. A. Messer,

S. Tendolkar,

Daniel J. Diekema

Publication year - 2011

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02432-10

Subject(s) - posaconazole , voriconazole , itraconazole , broth microdilution , microbiology and biotechnology , serial dilution , aspergillus , medicine , antifungal , antimicrobial , biology , minimum inhibitory concentration , pathology , alternative medicine

We compared EUCAST and CLSI antifungal susceptibility testing methods for itraconazole, posaconazole, and voriconazole by testing 245 Aspergillus clinical isolates. The essential agreement (EA) between methods was excellent: 100% (itraconazole), 98.4% (posaconazole), and 99.6% (voriconazole) assessing EA at ±2 dilutions and 99.6% (itraconazole), 87.7% (posaconazole), and 96.3% (voriconazole) at ±1 dilution.

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