Temporal and Spatial Compartmentalization of Drug-Resistant Cytomegalovirus (CMV) in a Child with CMV Meningoencephalitis: Implications for Sampling in Molecular Diagnosis | Zendy

Pierre Frange | Zendy; David Boutolleau | Zendy; Marianne LeruezVille | Zendy; Fabien Touzot | Zendy; Guilhem Cros | Zendy; Sébastien Héritier | Zendy; Despina Moshous | Zendy; Bénédicte Neven | Zendy; Alain Fischer | Zendy; Stéphane Blanche | Zendy

Open Access

Temporal and Spatial Compartmentalization of Drug-Resistant Cytomegalovirus (CMV) in a Child with CMV Meningoencephalitis: Implications for Sampling in Molecular Diagnosis

Author(s) -

Pierre Frange,

David Boutolleau,

Marianne LeruezVille,

Fabien Touzot,

Guilhem Cros,

Sébastien Héritier,

Despina Moshous,

Bénédicte Neven,

Alain Fischer,

Stéphane Blanche

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02411-13

Subject(s) - cytomegalovirus , meningoencephalitis , virology , betaherpesvirinae , biology , herpesviridae , human cytomegalovirus , immunology , drug resistance , viral disease , virus , microbiology and biotechnology

We describe a case of antiviral-resistant cytomegalovirus meningoencephalitis occurring after hematopoietic stem cell transplantation. Antiviral-resistant cytomegalovirus was identified in blood 16 months earlier. However, wild-type cytomegalovirus was evidenced in blood when the meningoencephalitis was diagnosed. Treatment of meningoencephalitis should be adapted to all previously identified resistance mutations in any compartment.

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