Open AccessSeven Hours to Adequate Antimicrobial Therapy in Urosepsis Using Isothermal Microcalorimetry
Author(s) -
Olivier Braissant,
Georg Müller,
Adrian Egli,
Andreas F. Widmer,
Reno Frei,
A. Halla,
Dieter Wirz,
Thomas C. Gasser,
Alexander Bachmann,
Florian Wagenlehner,
Gernot Bonkat
Publication year - 2013
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.02374-13
Subject(s) - isothermal microcalorimetry , septic shock , antimicrobial , sepsis , microbiology and biotechnology , isothermal process , antibiogram , medicine , biology , antibiotics , intensive care medicine , antibiotic resistance , physics , thermodynamics , enthalpy , quantum mechanics
Urosepsis can progress toward severe sepsis, septic shock, and, ultimately, death. Rapid antimicrobial susceptibility testing is crucial to decrease mortality and morbidity. This report shows that isothermal microcalorimetry can provide an antibiogram within 7 h with a sensitivity of 95% and specificity of 91% using Vitek-2 system as a reference.
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