Insertion Sequence 1515 in the ply Gene of a Type 1 Clinical Isolate of Streptococcus pneumoniae Abolishes Pneumolysin Expression | Zendy

Fabien Garnier | Zendy; Rajendra Prasad Janapatla | Zendy; Emmanuelle Charpentier | Zendy; Geoffrey Masson | Zendy; Carole Grélaud | Zendy; J Stach | Zendy; François Denis | Zendy; Marie-Cécile Ploy | Zendy

Open Access

Insertion Sequence 1515 in the ply Gene of a Type 1 Clinical Isolate of Streptococcus pneumoniae Abolishes Pneumolysin Expression

Author(s) -

Fabien Garnier,

Rajendra Prasad Janapatla,

Emmanuelle Charpentier,

Geoffrey Masson,

Carole Grélaud,

J Stach,

François Denis,

Marie-Cécile Ploy

Publication year - 2007

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02168-06

Subject(s) - pneumolysin , streptococcus pneumoniae , biology , microbiology and biotechnology , streptococcaceae , gene , sequence (biology) , bacterial protein , virology , genetics , antibiotics

A serotype 1 Streptococcus pneumoniae strain isolated by blood culture from a woman with pneumonia was found to harbor insertion sequence (IS) 1515 in the pneumolysin gene, abolishing pneumolysin expression. To our knowledge, this is the first report of an IS in the pneumolysin gene of S. pneumoniae.

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