Is a Two-Step Glutamate Dehyrogenase Antigen-Cytotoxicity Neutralization Assay Algorithm Superior to the Premier Toxin A and B Enzyme Immunoassay for Laboratory Detection of Clostridium difficile ? | Zendy

Peter H. Gilligan | Zendy

Open Access

Is a Two-Step Glutamate Dehyrogenase Antigen-Cytotoxicity Neutralization Assay Algorithm Superior to the Premier Toxin A and B Enzyme Immunoassay for Laboratory Detection of Clostridium difficile ?

Author(s) -

Peter H. Gilligan

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02100-07

Subject(s) - immunoassay , toxin , clostridium difficile , neutralization , microbiology and biotechnology , cytotoxicity , clostridium difficile toxin a , clostridiaceae , clostridium difficile toxin b , enzyme , biology , virology , antibiotics , biochemistry , in vitro , immunology , antibody , virus

A two-step algorithm for the detection ofClostridium difficile by the use of C. Diff Quik Chek (TechLab, Blacksburg, VA) and a tissue culture cytotoxicity neutralization assay was found to be more sensitive than the widely used solid-phase enzyme immunoassay (EIA), the Premier toxin A and B EIA (Meridian Bioscience, Cincinnati, OH), and a newly developed, rapid single-test EIA forC. difficile toxins A and B (Tox A/B Quik Chek; TechLab).

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