An Update on Clostridium difficile Toxinotyping | Zendy

Maja Rupnik | Zendy; Sandra Janežič | Zendy

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An Update on Clostridium difficile Toxinotyping

Author(s) -

Maja Rupnik,

Sandra Janežič

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02083-15

Subject(s) - clostridium difficile , biology , restriction fragment length polymorphism , locus (genetics) , clostridiaceae , microbiology and biotechnology , phylogenetic tree , pathogenicity , ribotyping , clostridium , genetics , polymerase chain reaction , bacteria , gene , toxin , antibiotics

Toxinotyping is a PCR-restriction fragment length polymorphism (RFLP)-based method for differentiation ofClostridium difficile strains according to the changes in the pathogenicity locus (PaLoc), a region coding for toxins A and B. Toxinotypes are a heterogenous group of strains that are important in the development of molecular diagnostic tests and vaccines and are a good basis forC. difficile phylogenetic studies. Here we describe an overview of the 34 currently known toxinotypes (I to XXXIV) and some changes in nomenclature.

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