Open AccessMucor circinelloides as a Cause of Invasive Maxillofacial Zygomycosis: an Emerging Dimorphic Pathogen with Reduced Susceptibility to Posaconazole
Author(s) -
Zia U. Khan,
Suhail Ahmad,
Arnost Brazda,
Rachel Chandy
Publication year - 2009
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.02030-08
Subject(s) - posaconazole , zygomycosis , mucor circinelloides , mucormycosis , amphotericin b , mucorales , biology , antifungal , microbiology and biotechnology , mucor , pathogen , medicine , pathology , aspergillus
A case of maxillofacial zygomycosis caused byMucor circinelloides , identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.