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A 57-year-old man who had recently undergone a transrectal prostate biopsy for a rising prostate-specific antigen level developed postbiopsy necrotizing epididymo-orchitis (requiring orchiectomy) and then Gram-negative meningitis, despite fluoroquinolone administration for periprocedural prophylaxis and subsequent therapy. The causative organism proved to be a fluoroquinolone-resistantEscherichia coli strain from sequence type ST131.

Post-Prostate Biopsy Infection with Escherichia coli ST131 Leading to Epididymo-Orchitis and Meningitis Caused by Gram-Negative Bacilli