Enzyme Immunoassay versus Latex Agglutination Cryptococcal Antigen Assays in Adults with Non-HIV-Related Cryptococcosis | Zendy

Anil A. Panackal | Zendy; John P. Dekker | Zendy; Michael A. Proschan | Zendy; Andrea Beri | Zendy; Peter R. Williamson | Zendy

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Enzyme Immunoassay versus Latex Agglutination Cryptococcal Antigen Assays in Adults with Non-HIV-Related Cryptococcosis

Author(s) -

Anil A. Panackal,

John P. Dekker,

Michael A. Proschan,

Andrea Beri,

Peter R. Williamson

Publication year - 2014

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.02017-14

Subject(s) - latex fixation test , immunoassay , cryptococcosis , agglutination (biology) , immunology , antigen , cerebrospinal fluid , biology , virology , microbiology and biotechnology , medicine , antibody , pathology

We compared paired enzyme immunoassay (EIA) and latex agglutination (LA) assay results with 185 blood and 164 cerebrospinal fluid (CSF) samples from 44 and 33 non-HIV cryptococcosis patients, respectively. The LA assay cutoff of 1:256 in the blood and 1:32 in the CSF was most highly predictive of a positive EIA result. The EIA missed 18.4% detected by the LA assay in the blood samples and 7.8% detected by the LA assay in the CSF samples. We note here the improved sensitivity of the LA assay over the EIA in non-HIV patients.

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