Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1 | Zendy

Thomas Åkerlund | Zendy; I. Persson | Zendy; Magnus Unemo | Zendy; Torbjörn Norén | Zendy; Bo Svenungsson | Zendy; Marlene Wullt | Zendy; Lars Burman | Zendy

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Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1

Author(s) -

Thomas Åkerlund,

I. Persson,

Magnus Unemo,

Torbjörn Norén,

Bo Svenungsson,

Marlene Wullt,

Lars Burman

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01964-07

Subject(s) - clostridium difficile , microbiology and biotechnology , biology , moxifloxacin , clostridium , virology , toxin , bacteria , antibiotics , genetics

Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the sametcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.

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