Open AccessIncreased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1
Author(s) -
Thomas Åkerlund,
I. Persson,
Magnus Unemo,
Torbjörn Norén,
Bo Svenungsson,
Marlene Wullt,
Lars Burman
Publication year - 2008
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01964-07
Subject(s) - clostridium difficile , microbiology and biotechnology , biology , moxifloxacin , clostridium , virology , toxin , bacteria , antibiotics , genetics
Clostridium difficile PCR ribotype 027 comprised 0.2% of a collection of Swedish isolates in 1997-2001 (3 of 1,325 isolates). These isolates had lower moxifloxacin MICs than the epidemic type 027 isolates, but they had the sametcdC sequence and toxin yield. Type 027 produced 3- to 13-fold more toxin than did major Swedish types. One epidemic strain (027/NAP1a) sporulated more than did other type 027 isolates, a feature that should contribute to its survival and spread.