Mycobacterium tuberculosis in Ontario, Canada: Insights from IS 6110 Restriction Fragment Length Polymorphism and Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Genotyping | Zendy

David C. Alexander | Zendy; Jennifer L. Guthrie | Zendy; Daria Pyskir | Zendy; Anne Maki | Zendy; Natalia Kurepina | Zendy; Barry N. Kreiswirth | Zendy; Pamela Chedore | Zendy; Steven J. Drews | Zendy; Frances Jamieson | Zendy

Open Access

Mycobacterium tuberculosis in Ontario, Canada: Insights from IS 6110 Restriction Fragment Length Polymorphism and Mycobacterial Interspersed Repetitive-Unit-Variable-Number Tandem-Repeat Genotyping

Author(s) -

David C. Alexander,

Jennifer L. Guthrie,

Daria Pyskir,

Anne Maki,

Natalia Kurepina,

Barry N. Kreiswirth,

Pamela Chedore,

Steven J. Drews,

Frances Jamieson

Publication year - 2009

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01946-08

Subject(s) - variable number tandem repeat , genotyping , restriction fragment length polymorphism , mycobacterium tuberculosis , tandem repeat , biology , genotype , tuberculosis , genetics , polymorphism (computer science) , virology , medicine , gene , pathology , genome

A collection of 1,308 clinical Mycobacterium tuberculosis isolates from Ontario, Canada, was genotyped by IS6110 restriction fragment length polymorphism (RFLP) and mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) analysis. RFLP or >12 MIRU-VNTR loci were necessary for resolution of Indo-Oceanic strains. The low clustering rate and high strain diversity indicate that, in Ontario, most tuberculosis results from reactivation of latent infections.

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