Preliminary Evaluation of the Research-Use-Only (RUO) iCubate iC-GPC Assay for Identification of Select Gram-Positive Bacteria and Their Resistance Determinants in Blood Culture Broths | Zendy

Blake W. Buchan | Zendy; G. C. Reymann | Zendy; Paul A. Granato | Zendy; Brenda R. Alkins | Zendy; Patricia Jim | Zendy; Stephen Young | Zendy

Open Access

Preliminary Evaluation of the Research-Use-Only (RUO) iCubate iC-GPC Assay for Identification of Select Gram-Positive Bacteria and Their Resistance Determinants in Blood Culture Broths

Author(s) -

Blake W. Buchan,

G. C. Reymann,

Paul A. Granato,

Brenda R. Alkins,

Patricia Jim,

Stephen Young

Publication year - 2015

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01934-15

Subject(s) - microbiology and biotechnology , staphylococcus epidermidis , streptococcus pneumoniae , enterococcus faecium , blood culture , enterococcus faecalis , enterococcus , biology , bacteria , staphylococcus aureus , gram positive bacteria , streptococcus , streptococcaceae , staphylococcus , micrococcaceae , antibacterial agent , antibiotics , genetics

The iC-GPC assay (iCubate, Huntsville, AL) provides a molecular option for the rapid, on-demand analysis of positive blood cultures. A preliminary evaluation of the iC-GPC assay using 203 clinical or seeded specimens demonstrated a sensitivity of 93.8% to 100% and a specificity of 98.0% to 100% for the identification of five Gram-positive bacterial species (Staphylococcus aureus ,Staphylococcus epidermidis ,Streptococcus pneumoniae ,Enterococcus faecalis , andEnterococcus faecium ) and three associated genetic resistance determinants (mecA ,vanA , andvanB ) in positive blood culture broths.

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