Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy | Zendy

Johanna Sandlund | Zendy; Kerrie Davies | Zendy; Mark H. Wilcox | Zendy

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Ultrasensitive Clostridioides difficile Toxin Testing for Higher Diagnostic Accuracy

Author(s) -

Johanna Sandlund,

Kerrie Davies,

Mark H. Wilcox

Publication year - 2020

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01913-19

Subject(s) - clostridioides , diagnostic accuracy , diagnostic test , guideline , clostridium difficile , toxin , medicine , c difficile , microbiology and biotechnology , biology , pathology , antibiotics , emergency medicine

Currently available diagnostic tests for Clostridioides difficile infection (CDI) lack specificity or sensitivity, which has led to guideline recommendations for multistep testing algorithms. Ultrasensitive assays for detection of C. difficile toxins provide measurements of disease-specific markers at very low concentrations. These assays may show improved accuracy compared to current testing methods and offer a potential standalone solution for CDI diagnosis, although large studies of clinical performance and accuracy are lacking.

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