Agammaglobulinemia and Staphylococcus aureus Botryomycosis in a Cohort of Related Sentinel Swiss Webster Mice | Zendy

Erin C. Bridgeford | Zendy; James G. Fox | Zendy; Prashant R. Nambiar | Zendy; Arlin B. Rogers | Zendy

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Agammaglobulinemia and Staphylococcus aureus Botryomycosis in a Cohort of Related Sentinel Swiss Webster Mice

Author(s) -

Erin C. Bridgeford,

James G. Fox,

Prashant R. Nambiar,

Arlin B. Rogers

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01875-07

Subject(s) - staphylococcus aureus , medicine , seroconversion , cohort , staphylococcal infections , immunology , dermatology , biology , human immunodeficiency virus (hiv) , bacteria , genetics

Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation in surveillance programs.

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