Open AccessConsistency of Influenza A Virus Detection Test Results across Respiratory Specimen Collection Methods Using Real-Time Reverse Transcription-PCR
Author(s) -
Sarah Spencer,
Manjusha Gaglani,
Allison L. Naleway,
Sue Reynolds,
Sarah Ball,
Sam Bozeman,
Emily Henkle,
Jennifer K. Meece,
Mary Vandermause,
Lydia Clipper,
Mark G. Thompson
Publication year - 2013
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01873-13
Subject(s) - reverse transcription polymerase chain reaction , virology , virus , influenza a virus , reverse transcriptase , medicine , real time polymerase chain reaction , orthomyxoviridae , prospective cohort study , biology , polymerase chain reaction , gene , messenger rna , biochemistry
In our prospective cohort study, we compared the performance of nasopharyngeal, oropharyngeal, and nasal swabs for the detection of influenza virus using real-time reverse transcription-PCR assay. Joint consideration of results from oropharyngeal and nasal swabs was as effective as consideration of results from nasopharyngeal swabs alone, as measured by sensitivity and noninferiority analysis.
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