The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant | Zendy

Philippe Simon | Zendy; Benjamin P. Holder | Zendy; Xavier Bouhy | Zendy; Yacine Abed | Zendy; Catherine A. A. Beauchemin | Zendy; Guy Boivin | Zendy

Open Access

The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant

Author(s) -

Philippe Simon,

Benjamin P. Holder,

Xavier Bouhy,

Yacine Abed,

Catherine A. A. Beauchemin,

Guy Boivin

Publication year - 2010

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01732-10

Subject(s) - neuraminidase , oseltamivir , mutant , virology , biology , mutation , neuraminidase inhibitor , viral replication , influenza a virus , virus , hemagglutinin (influenza) , microbiology and biotechnology , genetics , covid-19 , gene , medicine , disease , pathology , infectious disease (medical specialty)

Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.

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