Open AccessAirway Obstruction Is Increased in Pneumocystis -Colonized Human Immunodeficiency Virus-Infected Outpatients
Author(s) -
Alison Morris,
Travis Alexander,
Saba Radhi,
Lorrie Lucht,
Frank C. Sciurba,
Jay Kolls,
Ruma Srivastava,
Chad Steele,
Karen A. Norris
Publication year - 2009
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01712-09
Subject(s) - sputum , immunology , respiratory disease , immunopathology , airway obstruction , pneumocystis jirovecii , colonization , viral disease , biology , virology , sida , medicine , virus , human immunodeficiency virus (hiv) , microbiology and biotechnology , airway , lung , pathology , tuberculosis , surgery
We investigated the relationship ofPneumocystis colonization, matrix metalloprotease levels in sputum, and airway obstruction in a cohort of human immunodeficiency virus (HIV)-infected outpatients.Pneumocystis -colonized subjects had worse obstruction of airways and higher levels of matrix metalloprotease-12 in sputa, suggesting thatPneumocystis colonization may be important in HIV-associated chronic obstructive pulmonary disease.