Retrospective Analysis of False-Positive and Disputed Rifampin Resistance Xpert MTB/RIF Assay Results in Clinical Samples from a Referral Hospital in Hunan, China | Zendy

Peilei Hu | Zendy; Hongtai Zhang | Zendy; Joy Fleming | Zendy; Guofeng Zhu | Zendy; Shuai Zhang | Zendy; Yaguo Wang | Zendy; Fengping Liu | Zendy; Songlin Yi | Zendy; Zhongnan Chen | Zendy; Zhenhua Chen | Zendy; Binbin Liu | Zendy; Daofang Gong | Zendy; Li Wan | Zendy; Xingyun Wang | Zendy; YunHong Tan | Zendy; Liqiong Bai | Zendy; Lijun Bi | Zendy

Open Access

Retrospective Analysis of False-Positive and Disputed Rifampin Resistance Xpert MTB/RIF Assay Results in Clinical Samples from a Referral Hospital in Hunan, China

Author(s) -

Peilei Hu,

Hongtai Zhang,

Joy Fleming,

Guofeng Zhu,

Shuai Zhang,

Yaguo Wang,

Fengping Liu,

Songlin Yi,

Zhongnan Chen,

Zhenhua Chen,

Binbin Liu,

Daofang Gong,

Li Wan,

Xingyun Wang,

YunHong Tan,

Liqiong Bai,

Lijun Bi

Publication year - 2019

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01707-18

Subject(s) - referral , medicine , retrospective cohort study , virology , family medicine

Concerns about the specificity of the Xpert MTB/RIF (Xpert) assay have arisen, as false-positive errors in the determination ofMycobacterium tuberculosis complex (MTBC) infection and rifampin (RIF) resistance in clinical practice have been reported. Here, we investigated 33 cases where patients were determined to be RIF susceptible using the Bactec MGIT 960 (MGIT) culture system but RIF resistant using the Xpert assay.

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