Open AccessMechanisms of Linezolid Resistance among Staphylococci in a Tertiary Hospital
Author(s) -
Inmaculada QuilesMelero,
Rosa Gómez-Gil,
María Pilar RomeroGómez,
Ana María SánchezDíaz,
Manuela de Pablos,
Julio GarcíaRodríguez,
Avelino Gutiérrez,
Jesús Mingorance
Publication year - 2012
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01598-12
Subject(s) - 23s ribosomal rna , linezolid , staphylococcus epidermidis , microbiology and biotechnology , staphylococcus haemolyticus , staphylococcus aureus , tertiary care , biology , micrococcaceae , staphylococcal infections , gene , medicine , antibacterial agent , antibiotics , genetics , bacteria , vancomycin , rna , ribosome
The mechanisms of linezolid resistance among 86 staphylococcal isolates from two intensive care units were investigated. The most frequent was the G2576T mutation in the 23S rRNA (82%). The cfr gene was found in 17% of the isolates, seven S. aureus and eight S. epidermidis isolates. Four of the S. epidermidis isolates had the G2576T mutation and the cfr gene. In four S. haemolyticus isolates, the mechanism could not be identified.
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