Outbreak Caused by a Multidrug-Resistant Klebsiella pneumoniae Clone Carrying bla VIM-12 in a University Hospital | Zendy

Despina Tokatlidou | Zendy; Maria Tsivitanidou | Zendy; Spyros Pournaras | Zendy; Alexandros Ikonomidis | Zendy; Athanassios Tsakris | Zendy; D. Sofianou | Zendy

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Outbreak Caused by a Multidrug-Resistant Klebsiella pneumoniae Clone Carrying bla _VIM-12 in a University Hospital

Author(s) -

Despina Tokatlidou,

Maria Tsivitanidou,

Spyros Pournaras,

Alexandros Ikonomidis,

Athanassios Tsakris,

D. Sofianou

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01573-07

Subject(s) - klebsiella pneumoniae , integron , microbiology and biotechnology , imipenem , clone (java method) , biology , plasmid , outbreak , transferability , pulsed field gel electrophoresis , multiple drug resistance , virology , antibiotics , antibiotic resistance , gene , genotype , escherichia coli , genetics , statistics , mathematics , logit

From November 2006 to April 2007, nine nonrepetitive isolates of Klebsiella pneumoniae with reduced susceptibility or resistance to carbapenems were recovered from clinical specimens from separate patients hospitalized in a tertiary care hospital. The imipenem-EDTA synergy test was positive for all isolates. PCR, sequencing, and transferability experiments revealed the novel bla(VIM-12) metallo-beta-lactamase gene, which was plasmid mediated and located in a class 1 integron. Pulsed-field gel electrophoresis demonstrated a single macrorestriction pattern, indicating the clonal spread of VIM-12-producing K. pneumoniae.

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