Open AccessPresence of the exoU Gene of Pseudomonas aeruginosa Is Correlated with Cytotoxicity in MDCK Cells but Not with Colonization in BALB/c Mice
Author(s) -
Hsi Hsun Lin,
Shiao Ping Huang,
Hsiu Chen Teng,
Dar Der Ji,
Yao Shen Chen,
Ya Lei Chen
Publication year - 2006
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01531-06
Subject(s) - pseudomonas aeruginosa , cytotoxicity , microbiology and biotechnology , biology , colonization , pseudomonadaceae , gene , pseudomonadales , pseudomonas , cell culture , bacteria , genetics , in vitro
A total of 141 independent strains ofPseudomonas aeruginosa with different heterogeneities in theexo gene (exoS ,exoT ,exoU , andexoY ) background were examined for their pathogenic roles. Results indicated that theexoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.