Presence of the exoU Gene of Pseudomonas aeruginosa Is Correlated with Cytotoxicity in MDCK Cells but Not with Colonization in BALB/c Mice | Zendy

Hsi-Hsun Lin | Zendy; Shiao-Ping Huang | Zendy; Hsiu-Chen Teng | Zendy; Dar-Der Ji | Zendy; Yao-Shen Chen | Zendy; Ya-Lei Chen | Zendy

Open Access

Presence of the exoU Gene of Pseudomonas aeruginosa Is Correlated with Cytotoxicity in MDCK Cells but Not with Colonization in BALB/c Mice

Author(s) -

Hsi-Hsun Lin,

Shiao-Ping Huang,

Hsiu-Chen Teng,

Dar-Der Ji,

Yao-Shen Chen,

Ya-Lei Chen

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01531-06

Subject(s) - pseudomonas aeruginosa , cytotoxicity , microbiology and biotechnology , biology , colonization , pseudomonadaceae , gene , pseudomonadales , pseudomonas , cell culture , bacteria , genetics , in vitro

A total of 141 independent strains ofPseudomonas aeruginosa with different heterogeneities in theexo gene (exoS ,exoT ,exoU , andexoY ) background were examined for their pathogenic roles. Results indicated that theexoU gene is the major contributor to cytotoxicity in Madin-Darby canine kidney cells but is not related to bacterial colonization in mice.

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