Evolution of Central Nervous System Multidrug-Resistant Mycobacterium tuberculosis and Late Relapse of Cryptic Prosthetic Hip Joint Tuberculosis: Complications during Treatment of Disseminated Isoniazid-Resistant Tuberculosis in an Immunocompromised Host | Zendy

Arlo Upton | Zendy; Andrew Woodhouse | Zendy; R Vaughan | Zendy; Sandie Newton | Zendy; R. B. EllisPegler | Zendy

Open Access

Evolution of Central Nervous System Multidrug-Resistant Mycobacterium tuberculosis and Late Relapse of Cryptic Prosthetic Hip Joint Tuberculosis: Complications during Treatment of Disseminated Isoniazid-Resistant Tuberculosis in an Immunocompromised Host

Author(s) -

Arlo Upton,

Andrew Woodhouse,

R Vaughan,

Sandie Newton,

R. B. EllisPegler

Publication year - 2008

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01473-08

Subject(s) - tuberculosis , isoniazid , mycobacterium tuberculosis , mycobacterium tuberculosis complex , medicine , virology , biology , pathology

We report a case of disseminated isoniazid-resistant tuberculosis in an immunocompromised patient with evolution of rifampin (rifampicin) resistance in the central nervous system. This was cured with intraventricular and oral treatment but was followed by a late relapse of the original infection in a prosthetic hip joint. We provide drug levels in cerebrospinal fluid and serum.

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