Complex Association of Virus- and Host-Related Factors with Hepatocellular Carcinoma Rate following Hepatitis C Virus Clearance | Zendy

Norio Akuta | Zendy; Fumitaka Suzuki | Zendy; Hitomi Sezaki | Zendy; Masahiro Kobayashi | Zendy; Shunichiro Fujiyama | Zendy; Yusuke Kawamura | Zendy; Tetsuya Hosaka | Zendy; Mariko Kobayashi | Zendy; Satoshi Saitoh | Zendy; Yoshiyuki Suzuki | Zendy; Yasuji Arase | Zendy; Kenji Ikeda | Zendy; Hiromitsu Kumada | Zendy

Open Access

Complex Association of Virus- and Host-Related Factors with Hepatocellular Carcinoma Rate following Hepatitis C Virus Clearance

Author(s) -

Norio Akuta,

Fumitaka Suzuki,

Hitomi Sezaki,

Masahiro Kobayashi,

Shunichiro Fujiyama,

Yusuke Kawamura,

Tetsuya Hosaka,

Mariko Kobayashi,

Satoshi Saitoh,

Yoshiyuki Suzuki,

Yasuji Arase,

Kenji Ikeda,

Hiromitsu Kumada

Publication year - 2018

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01463-18

Subject(s) - hepatitis c virus , hepatocellular carcinoma , virus , virology , host factors , hepacivirus , genotype , medicine , hepatitis c , liver disease , flaviviridae , viral disease , viral load , immunology , biology , gene , biochemistry

Little is known about the effects of virus- and host-related factors on hepatocarcinogenesis in patients who show viral clearance after HCV RNA eradication by direct-acting antivirals (DAAs). The subjects of this retrospective study were 1,922 patients with HCV genotype 1 (HCV-1)- or HCV-2-related chronic liver disease who showed a sustained virological response (SVR; defined as negative results for HCV RNA at 12 weeks after the cessation of all-oral DAAs).

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