Open AccessImpact of Mutations at Amino Acid 70 in Hepatitis C Virus (HCV) Genotype 1b Core Region on Hepatocarcinogenesis following Eradication of HCV RNA
Author(s) -
Norio Akuta,
Fumitaka Suzuki,
Masahiro Kobayashi,
Hitomi Sezaki,
Yusuke Kawamura,
Tetsuya Hosaka,
Mariko Kobayashi,
Satoshi Saitoh,
Yoshiyuki Suzuki,
Yasuji Arase,
Kenji Ikeda,
Hiromitsu Kumada
Publication year - 2015
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01457-15
Subject(s) - hepatocellular carcinoma , hepatitis c virus , genotype , biology , virology , hepacivirus , mutant , flaviviridae , hepatitis c , virus , genetics , gene
The impact of the HCV genotype 1b core amino acid (aa) 70 mutant on the cumulative rate of hepatocellular carcinoma following eradication of HCV RNA by antiviral therapy was investigated with the Q-Invader assay. Multivariate analysis based on 649 patients indicated that a core aa70 Q-Invader mutant level ≥20% is a predictor of hepatocellular carcinoma.
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