Combined Hepatitis C Virus (HCV) Antigen-Antibody Detection Assay Does Not Improve Diagnosis for Seronegative Individuals with Occult HCV Infection | Zendy

Juan Antonio Quiroga | Zendy; Inmaculada Castillo | Zendy; Margarita Pardo | Zendy; Elena RodríguezIñigo | Zendy; Vicente Carréño | Zendy

Open Access

Combined Hepatitis C Virus (HCV) Antigen-Antibody Detection Assay Does Not Improve Diagnosis for Seronegative Individuals with Occult HCV Infection

Author(s) -

Juan Antonio Quiroga,

Inmaculada Castillo,

Margarita Pardo,

Elena RodríguezIñigo,

Vicente Carréño

Publication year - 2006

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01440-06

Subject(s) - occult , hepatitis c virus , antibody , virology , antigen , medicine , serology , immunology , virus , hepatitis c , hepacivirus , viral disease , pathology , alternative medicine

A combined hepatitis C virus (HCV) antigen-antibody assay was evaluated for 115 seronegative individuals with occult HCV infection. The assay was reactive in one patient and negative to weakly reactive in three others (all four gave indeterminate results by supplemental assay) but failed to detect HCV in the remaining patients. Despite increased sensitivity the combined assay does not improve serodiagnosis of occult HCV infection.

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