Is Real-Time PCR Better than Conventional PCR for Mycobacterium tuberculosis Complex Detection in Clinical Samples? | Zendy

Enrico Tortoli | Zendy; Pasquale Urbano | Zendy; Fiorella Marcelli | Zendy; Tullia M. Simonetti | Zendy; Daniela María Cirillo | Zendy

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Is Real-Time PCR Better than Conventional PCR for Mycobacterium tuberculosis Complex Detection in Clinical Samples?

Author(s) -

Enrico Tortoli,

Pasquale Urbano,

Fiorella Marcelli,

Tullia M. Simonetti,

Daniela María Cirillo

Publication year - 2012

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01412-12

Subject(s) - mycobacterium tuberculosis , taqman , tuberculosis , mycobacterium tuberculosis complex , medicine , virology , polymerase chain reaction , biology , microbiology and biotechnology , pathology , gene , genetics

Cobas Amplicor MTB and later Cobas TaqMan MTB were used to test a very large series of consecutive specimens received for tuberculosis diagnosis. Performance parameters were estimated and compared overall and for separate specimen categories. Both systems showed excellent specificity, and that of TaqMan was the higher. The sensitivities were similar but satisfactory only with respiratory specimens and smear-positive samples.

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