Culture-Negative Prosthetic Valve Endocarditis with Concomitant Septicemia Due to a Nontoxigenic Corynebacterium diphtheriae Biotype Gravis Isolate in a Patient with Multiple Risk Factors | Zendy

Lani Clinton | Zendy; Matthew J. Bankowski | Zendy; Teppei Shimasaki | Zendy; Wichit SaeOw | Zendy; A. Christian Whelen | Zendy; Norman P. O’Connor | Zendy; Wesley Kim | Zendy; Royden S. Young | Zendy

Open Access

Culture-Negative Prosthetic Valve Endocarditis with Concomitant Septicemia Due to a Nontoxigenic Corynebacterium diphtheriae Biotype Gravis Isolate in a Patient with Multiple Risk Factors

Author(s) -

Lani Clinton,

Matthew J. Bankowski,

Teppei Shimasaki,

Wichit SaeOw,

A. Christian Whelen,

Norman P. O’Connor,

Wesley Kim,

Royden S. Young

Publication year - 2013

Publication title -

journal of clinical microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.349

H-Index - 255

eISSN - 1070-633X

pISSN - 0095-1137

DOI - 10.1128/jcm.01403-13

Subject(s) - corynebacterium diphtheriae , microbiology and biotechnology , biology , corynebacterium , bacteremia , endocarditis , diphtheria , virology , medicine , bacteria , antibiotics , vaccination , genetics

A 54-year-old female with a prosthetic mitral valve presented with a 3-day history of dizziness, subjective fever, and chills. Blood cultures were positive for a pleomorphic Gram-positive rod. Initial phenotypic testing could only support the identification of a Corynebacterium species. Nucleic acid sequencing (16S rRNA) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) were conclusive for Corynebacterium diphtheriae. Definitive phenotypic testing classified the strain as nontoxigenic C. diphtheriae biotype Gravis.

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