Open AccessTailoring Antimicrobial Susceptibility Testing to Individual Species of Coagulase-Negative Staphylococci: Next Up, Staphylococcus epidermidis
Author(s) -
C. Paul Morris,
Patricia J. Simner
Publication year - 2019
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01391-19
Subject(s) - staphylococcus epidermidis , microbiology and biotechnology , coagulase , cons , sccmec , staphylococcus , penicillin binding proteins , penicillin , antimicrobial , biology , staphylococcus haemolyticus , antibiotic resistance , staphylococcal infections , staphylococcus aureus , antibiotics , medicine , methicillin resistant staphylococcus aureus , bacteria , genetics , programming language , computer science
Accurate detection of methicillin resistance among staphylococci is vital for patient care. Methicillin resistance is most commonly mediated by acquisition of themecA gene, which encodes an altered penicillin binding protein, PBP2a. Application of phenotypic methods to detectmecA -mediated beta-lactam resistance in staphylococci is becoming more complex as species-specific differences are identified among coagulase-negative staphylococci (CoNS).
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