Open Accessbla VIM-2 and bla VIM-7 Carbapenemase-Producing Pseudomonas aeruginosa Isolates Detected in a Tertiary Care Medical Center in the United States: Report from the MYSTIC Program
Author(s) -
Halim Aboufaycal,
Hélio S. Sader,
Kenneth V. I. Rolston,
Lalitagauri M. Deshpande,
Mark A. Toleman,
Gerald P. Bodey,
Issam Raad,
Ronald N. Jones
Publication year - 2007
Publication title -
journal of clinical microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.349
H-Index - 255
eISSN - 1070-633X
pISSN - 0095-1137
DOI - 10.1128/jcm.01351-06
Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , meropenem , biology , tertiary care , polymyxin b , pseudomonadaceae , bacteria , antibiotics , medicine , antibiotic resistance , genetics , family medicine
Two Pseudomonas aeruginosa strains resistant to beta-lactams, fluoroquinolones, aminoglycosides, tetracyclines, and carbapenems and susceptible only to polymyxin B (MIC <or= 2 microg/ml) were identified as part of the Meropenem Yearly Susceptibility Test Information Collection program. Metallo-beta-lactamase screening tests were positive, PCR yielded products with blaVIM primers, and sequence analysis revealed blaVIM-7 and blaVIM-2. The isolates had distinct ribotype and pulsed-field gel electorphoresis patterns and appeared independently, remote in time and location, at the same cancer center.